Myasthenia gravis (MG) results from a disruption in signaling between nerves and muscles. This disruption happens in the neuromuscular junction (NMJ), the place where the nerve cells and muscles communicate. Generalized myasthenia gravis (gMG) is a more severe form of MG.
RYSTIGGO works by targeting and blocking an immune system protein called FcRn (neonatal Fc receptor), an underlying cause of gMG.*
*The exact mechanism by which RYSTIGGO works in gMG is unknown.
Watch the video below to learn more about how RYSTIGGO works.
Understanding Treatment Cycles and Breaks
RYSTIGGO is given once weekly over 6-week cycles. You will receive 6 doses in total, 1 week apart.
This 6-week period is called a treatment cycle. Every cycle is followed by a break in your RYSTIGGO treatment. During this break, you can work with your doctor to make a plan for future cycles, if needed.
Why is RYSTIGGO administered in 6-week treatment cycles?
RYSTIGGO dosing is based on how RYSTIGGO was studied in clinical trials and the final approval by the FDA. Your healthcare provider may start subsequent treatment cycles based on clinical evaluation.
Do I have to attend all 6 infusion appointments?
The recommended dose is administered once weekly for 6 weeks. It is important to attend all infusion appointments as indicated unless otherwise instructed by your doctor.
What if I miss an infusion appointment?
You should always contact your healthcare provider immediately if a dose is missed. In most cases, RYSTIGGO may be administered up to 4 days after the scheduled time. Thereafter, resume the original dosing schedule until the treatment cycle is completed.
How many 6-week treatment cycles do I need?
Most people may require repeated cycles of RYSTIGGO to manage their gMG symptoms. Everyone responds to treatment differently, so it is important to monitor your progress. After your treatment cycle, work with your doctor to determine if or when another cycle is needed.
What is the treatment break?
The treatment break is the time between treatment cycles. The length of your breaks will be based on individual treatment experience and your doctor’s clinical judgment. However, the safety of starting later cycles sooner than 63 days from the start of the previous treatment cycle has not been established. It’s important to keep track of any gMG symptoms that may return during breaks from treatment. During this treatment break, you don’t attend infusion appointments—you simply keep track of how you feel and whether you see changes in your symptoms. You should communicate any changes in your symptoms to your healthcare provider, as they will determine if or when you need additional treatment cycles based on a clinical evaluation of your symptoms.
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