Myasthenia gravis (MG) results from a disruption in signaling between nerves and muscles. This disruption happens in the neuromuscular junction (NMJ), the place where the nerve cells and muscles communicate. Generalized myasthenia gravis (gMG) is a more severe form of MG.
ZILBRYSQ blocks C5, a specific complement protein involved in muscle cell damage. By reducing the cause of the muscle cell damage, ZILBRYSQ can help improve those signals between nerves and muscles.*
*The exact mechanism by which ZILBRYSQ works in gMG is unknown.
Watch the video below to learn more about how ZILBRYSQ works.
For more information on ZILBRYSQ, visit:
A Risk Evaluation and Mitigation Strategy (REMS) is a drug safety program that the U.S. Food and Drug Administration (FDA) requires for certain medications to ensure they are used safely. When there is a REMS, drug companies and healthcare providers must take extra steps to make sure the benefits of using the drug are greater than the risks. ZILBRYSQ is only available through a program called the ZILBRYSQ REMS.
ZILBRYSQ has a REMS because it increases your chance of getting a meningococcal infection. This infection can quickly become life-threatening or cause death if not recognized and treated early.
Before you can receive ZILBRYSQ, your healthcare provider will:
- counsel you about the risk of meningococcal infection.
- give you the Patient Guide, including information about the signs and symptoms of meningococcal infection.
- give you a Patient Safety Card about your risk of meningococcal infection, as discussed above.
- make sure that you are vaccinated against serious infections caused by meningococcal bacteria and that you receive antibiotics if you need to start ZILBRYSQ right away and you are not up to date on your vaccines.
Ensuring your vaccines are up to date can sometimes take time, and that’s normal. During this time, you can stay in touch with your Care Coordinator, ask questions, and make sure you are clear on next steps.
To learn more about ZILBRYSQ REMS and vaccination requirements, visit:
After you’ve been prescribed ZILBRYSQ, ONWARD works with a team at specialty pharmacy PANTHERx Rare that will assist with your transition to your new therapy and will also coordinate prescription delivery.
PANTHERx Rare will continue to work closely with you and your prescriber to help ensure that you are able to schedule future shipments and deliveries of ZILBRYSQ with ease.
Contact PANTHERx Rare at 833-418-7760
You can also reach out to your ONWARD Care Coordinator if you have any questions or want help connecting with PANTHERx.
